Senior Thesis Titles 1999

David T. Boyd

The role of Chondroitin-4-Sulfate (CSA) in the cytoadherence of Plasmodium falciparum to the trophoblast.
Diane W. Taylor, Department of Biology, Georgetown University

Natalie C. Breheny

Evaluation of alternative modes of treatment for pediatric patients suffering from Acute Respiratory Distress Syndrome.
Department of Pediatric Intensive Care Unit, Georgetown University Medical Center, Dr. Anne Rosenwald, Department of Biology, Georgetown University

Elizabeth Buerkle

Electron microscopy and genetic characterization of the phytoplasma infecting a black locust tree.
George B. Chapman, Department of Biology, Georgetown University

Brian Scott Caldwell

Population studies of Diadema antillarum at Great Abaco Island, Bahamas.
Phillip Sze, Department of Biology, Georgetown University

Marisa Cappiello

The influence of N-acetylaspartylglutamate (NAAG) selective activation of group II metabotrophic glutamate receptor mBluR3 on the presynaptic release of gamma aminobutyric acid (GABA).
Joseph H. Neale, Department of Biology, Georgetown University

Lisa Anne Collea

Comparing the accuracy of hypermetaphase versus interphase fluorescence in situ hybridization in the diagnosis of chromosome translocations in patients with leukemia.
Jeanne Meck, Ph.D., Department of Obstetrics and Gynecology, Division of Genetics, Institute for Molecular and Human Genetics, Georgetown University Medical Center
Ronda Rolfes, Ph.D., Department of Biology, Georgetown University

Michelle Collins

HLA-DRB1*01 Allele Frequencies in U.S. Populations:  Implications for Stem Cell Transplantation
Michelle Collins, Noriko Steiner, and Carolyn Katovich Hurley, Department of Microbiology and Immunology, GUMC and Naval Medical Research Institute, Bethesda, MD

Meghan Cunningham

The effects of telomerase inhibitors on uptake, incorporation and phosphorylation of 3H-thymidine Lytechinus pictus embryos.
David Nishioka, Ph.D., Department of Biology, Georgetown University

Maggie Czarnogorski

Evidence of a Phosphate Appetite in Adult Rats.
Dr. Susan Mulroney, Department of Physiology, Georgetown University
Dr. Richard Blanquet, Department of Biology, Georgetown University

Brian D’Cruz

Synaptic Plasticity as a Basis for Short-Term and Long-Term Memory in Animals:  A Comparative Review
Joseph Neale, Department of Biology, Georgetown University

Phillip De Biase

Identification of new regulatory proteins for purine biosynthesis
Ronda Rolfes, Department of Biology, Georgetown University

John P. Dunleavy

A detailed study of the testis of a carpenter bee (Xylocopa virginica virginica) using both electron and light microscopy.
George B. Chapman, Department of Biology, Georgetown University

Karen A. Ertel

Menopause: Adaptive function in humans and whales?
Dr. Janet Mann, Department of Biology, Georgetown University

Jason Gajarsa

Transacting factors in the human endogenous retrovirus-like element HERV.E.-PTN in the promoter region of the growth factor PTN.
Anke Schulte, Department of Pharmacology, Georgetown University

Lauren Elizabeth Galpin

The regulation of GABA-A receptor subunit expression in cerebellar granule cells by NAAG via a second messenger system
Joseph Neale, Ph.D., Barbara Wroblewska, Ph.D., Georgetown University

Kirana Gudi

The effects of the ketogenic diet on strychnine-induced seizures in rats.
Douglas A. Eagles, Department of Biology, Georgetown University

Frederick T. Han

A preliminary evaluation of the efficacy of the ketogenic diet upon picrotoxin-induced seizures in Sprague-Dawley rats.
Douglas A. Eagles, Department of Biology, Georgetown University

Serita R. Holness

 Effects of Melatonin and Serotonin on Premenstrual Dysphoric Disorder.
Douglas A. Eagles, Department of Biology, Georgetown University

Edward C. Hwang

Brefeldin A and Suppression of Cancer Cell Invasion:  The Search for a Mechanism
Susette C. Mueller, Department of Cell Biology, Georgetown University Medical Center, Ellen J. Henderson, Department of Biology, Georgetown University

Winnie Anne Imperio

The physiological and biochemical adaptation of the African lungfish to estivation.
Richard Blanquet, Department of Biology, Georgetown University

Krista Irwin

The development of foraging specializations among wild bottlenose dolphin calves in Shark Bay, Australia
Professor Janet Mann, Department of Biology, Georgetown University

John M. Jordan

The feasibility of Gene Therapy as a Cure for Severe Combined Immunodeficiency (SCID).
Ronda J. Rolfes, Department of Biology, Georgetown University

Merium Kamran Khan

The Effects of TR-1 and TR-2 on Telomerase in Sea Urchin Embryos.
David Nishioka, Ph.D., Department of Biology, Georgetown University

Amit Khanna

Defective herpes simplex virus vectors for gene transfer to cells of the central nervous system:  The study of petunia glutamic acid decarboxylase (pGAD)
Samuel Rabkin, Department of Neurosurgery, Georgetown University Medical Center, Joseph Neale, Department of Biology, Georgetown University

Seth Kostek

Analysis of Arl1[Q72L] in Saccharomyces cerevisiae
Dr. Anne G. Rosenwald, Department of Biology, Georgetown University

Shawna Lagan

Human Immunodeficiency Virus Resistance in Humans
Dr. Diane W. Taylor, Department of Biology, Georgetown University

Kathryn E. Landau

The Serotonin-Endorphin connection:  the tie that binds depression to eating disorders and other addictive behaviors
Dr. Joseph H. Neale, Ph.D., Professor and Chair of the Biology Department at Georgetown University

James Lister

The evolutionary analysis of receptor proteins for nerve growth factor and brain-derived neurotrophin factor.
John S. Garavelli, National Biomedical Research Foundation, Georgetown University Medical Center, Matthew B. Hamilton, Department of Biology, Georgetown University

Jamie Mallah

The role of the Ang-1/Tie-2 system in angiogenesis and endothelial cell survival
Lu-Yuan Li, Lombardi Cancer Center, Georgetown University, Anne G. Rosenwald, Department of Biology, Georgetown University

Patrick Matthews

An evaluation of the ketogenic diet versus seizures induced via maximal electroconvulsive shock.
Douglas A. Eagles, Department of Biology, Georgetown University

Kevin McGill

Stridulation in Leaf-Cutting Ants
Professor Martha Weiss, Department of Biology, Georgetown University

Jennifer Mitchell

The Relationship Between Physical Condition and Reproductive Behavior in Male Harbor Seals, Phoca vitulina
Daryl Boness, Ph.D., National Zoological Park, Washington, DC, Janet Mann, Ph.D., Department of Biology, Georgetown University

Athir H. Morad

Cortical Processing of Vowel Sounds as Revealed with functional Magnetic Resonance Imaging
Dr. Josef Rauschecker, Georgetown Institute for Cognitive and Computational Sciences, Dr. Joseph Neale, Department of Biology, Georgetown University
* Athir was awarded the Chapman Medal from the Department of Biology for this thesis research project

Ellen M. Mowry

Sequence analysis and identification of differentially expressed genes in monozygotic twins discordant for multiple sclerosis and screening for the expression of these genes in multiple sclerosis patients versus non-multiple sclerosis individuals.
John R. Richert, M.D. and Chair, Department of Microbiology and Immunology, Georgetown University Medical Center, and Douglas A. Eagles, Ph.D., Department of Biology, Georgetown University

Anne Marie Mulle

Destruction Screening:  a new method to evaluate/identify tumor suppressors
Dr. Peter Burbelo and Dr. Anne Rosenwald, Georgetown University

Robert G. Najarian

The distribution of specific atrial granules and the identification of nerve processes within rat atrial cardiac muscle.
George B. Chapman, Department of Biology, Georgetown University

Hien T. Nguyen

A large-scale analysis of genes involved in breast cancer progression using cDNA microarrays.
Yan A. Su, Institute for Molecular and Human Genetics, Lombardi Cancer Center
Ronda J. Rolfes, Department of Biology, Georgetown University

Nhu T. Nguyen

Sociosexual development in bottlenose dolphin calves
Janet Mann, Department of Biology, Georgetown University

Tisola A. Noel-Birdsong

The pattern of neuronal damage induced by status epilepticus evoked from area tempestas.
Alexi Kondratyev, Department of Pharmacology, Georgetown University Medical Center, Dr. Douglas Eagles, Department of Biology, Georgetown University

Michael A. Oppedisano

The role of glutamate transmission in the substantia nigra pars reticulata in the control of posture and movement.
Karen Gale, Ph.D., David Dybdal, Department of Pharmacology, Georgetown University Medical Center, George B. Chapman, Ph.D., Department of Biology, Georgetown University

Niraj Pahlajani

Expression of FGF-BP Isoforms and the Relation to Angiogenesis, Tumorous Condition, and Tissue Type
Lombardi Cancer Center and Department of Pharmacology, Georgetown University

Jennifer Pietruski

Ecological engineering approaches to the control of cultural eutrophication.
Philip Sze, Department of Biology, Georgetown University

Sean Raft

Flight of the Dragonfly
Richard S. Blanquet, V.M., Associate Professor of Biology, Georgetown University

Alyssa H. Rathod

The effects of the ketogenic diet on generalized absence seizures in male Sprague-Dawley rats.
Douglas A. Eagles, Department of Biology, Georgetown University

Kiran Reddy

The Use of the OspB Competitive Polymerase Chain Reaction in the Localization and Quantification of Borrelia burgdorferi in a nonhuman primate with Lyme Neuroborreliosis.
Andrew Pachner, Georgetown University Department of Neurology

Maura Reddington

The Use of the Insulin-like Growth Factor 1 Receptor Gene as a Prognostic Marker in Breast Cancer.
Matthew Ellis, Lombardi Cancer Center, Georgetown University Medical Center, Joseph Neale, Department of Biology, Georgetown University

Norelle Rizkalla

Characterization of Apoptosis Pathways in Prostate Cancer Cells
Edward P. Gelmann, M.D., Kotohiko Kimura, Ph.D., Division of Hematology/Oncology, Department of Medicine, Lombardi Cancer Center, Georgetown University, Ellen J. Henderson, Ph.D., Department of Biology, Georgetown University

Christopher P. Ruisi

The effects of the co-expression of the NMDA receptor and glutamate transporter GLT-1 in LIMTK-cells.
Barry B. Wolfe and Robert Yasuda, Department of Pharmacology, Georgetown University School of Medicine, Joseph H. Neale, Department of Biology, Georgetown University

Arlene P. Santos

The effect of muscle cell differentiation on the protein expression levels and subcellular localization of the postsynaptic muscle proteins: Src and Fyn.
Sheridan L. Swope, Georgetown Institute for Cognitive and Computational Sciences, Georgetown University Medical Center, Douglas A. Eagles, Department of Biology, Georgetown University

Michael Selden

Rejection Rates in Post-Heart Transplant Recipients
Dr. Nelson Burton, Transplant Department at Fairfax Hospital
Dr. David Hull, Transplant Department at Hartford Hospital
Dr. George Chapman, Department of Biology, Georgetown University

Kerri Anne Smedley

Maternal Investment in Bottlenose Dolphins
Janet Mann, Ph.D., Department of Biology, Georgetown University

Brian N. Smith

Flower Flies (Diptera: Syrphidae), biodiversity, and edge effect in Dyke Marsh Wildlife Preserve, Virginia.
Edward M. Barrows, Laboratory of Entomology and Animal Behavior, Department of Biology, Georgetown University

Heather Stark

The Neonatal Immune System
Dr. Diane Taylor, Department of Biology, Georgetown University

Roderick Tan

Potential Involvement of the Macrophage in the Morphine-induced Suppression of Lymphocyte Proliferation
Barbara M. Bayer, Department of Pharmacology, Georgetown University Medical Center, Joseph H. Neale, Department of Biology, Georgetown University

Ellen Turk

The Influence of Sickle Cell Trait on Antibodies to Plasmodium falciparum
Dr. Diane Taylor, Department of Biology, Georgetown University

Ritu Valiyil

Injection and infusion of the ketone bodies ß-hydroxybutyrate and acetoacetate exhibit no effects upon seizure resistance.
Douglas A. Eagles, Department of Biology, Georgetown University

Jee Vang

The Carboxyl-terminal tail of a1C L-type Ca2+ Channel Directly Modulates Ryanodine Receptor Incorporated in Lipid Bilayer
Dr. Nikolai M. Soldatov, Georgetown University
Dr. Martin Morad, Georgetown University
Dr. Joseph Neale, Department of Biology, Georgetown University

Christopher M. Watson

Bee Diversity and a Search for an Edge Effect in a Tidal Freshwater Marsh (Hymenoptera: Apiformes)
Edward M. Barrows, the Laboratory of Entomology and Animal Behavior, Department of Biology, Georgetown University

Janet Willoughby

An Investigation of the Functional Inactivation and Phosphorylation of Neuronal a3/ß4 Nicotinic Acetylcholine Receptors
Kenneth Kellar, Department of Pharmacology, Georgetown University Medical Center, Douglas A. Eagles, Department of Biology, Georgetown University

Julia M. Wren

A structure-function analysis of BAS2:  mapping the interaction domain
Ronda Rolfes, Ph.D., Department of Biology, Georgetown University

Catherine Yankelevich

Structural and functional analysis of the Bas2p protein from the yeast Saccharomyces cerevisiae
Ronda Rolfes, Department of Biology, Georgetown University

Suellan Yao

More protection against seizures without neurotoxicity is afforded by higher ketogenic ratios.
Douglas A. Eagles, Department of Biology, Georgetown University