Professor Joseph H. Neale of Biology department recently published a paper in the Neurobiology of Learning and Memory.
February 1st, 2019
Joseph H. Neale, Professor of Biology at Georgetown University, along with Dr. Rafal Olszewski at the National Institute on Deafness and Other Communication Disorders (NIDCD), recently published a paper in the Neurobiology of Learning and Memory. Neale and Olszewski uncover recent findings on the importance of NAAG, the third most prevalent peptide neurotransmitter in the mammalian nervous system. They conclude that GCPII (glutamate carboxypeptidases II) inhibitors, inhibitors which reduce the rate of inactivation of NAAG, increase synaptic NAAG and affect cognition in animal models of Alzheimer’s disease, inflammatory pain, and ethanol intoxication. With their recent findings, Neale and Olszewski inspire future research on defining the procognitive role of NAAG and GCPII inhibitors, and understanding the role of NAAG and GCPII on higher cognitive processes such as learning, memory formation, and attention.