Publications

Selected Publications from 2000-present
From more than 40 papers on NAAG

Neale, J. H., Bzdega, T., and B. Wroblewska. N-Acetylaspartylglutamate: The most abundant peptide neurotransmitter in the mammalian central nervous system. J. Neurochemistry. 75:443-452, 2000.

Lea, P.M., Wroblewska, B., Sarvey, J. M. and J. H. Neale. Beta-NAAG rescues LTP from blockade by NAAG in the rat dentate gyrus via the type 3 metabotropic glutamate receptor J. Neurophysiology 85:1097-1106, 2001..

Zhao, J., Cappiello, M., Ramadan, E., Wroblewska, B,. Bzdega, T. and J. H. Neale. NAAG inhibits [3H]-GABA release via mGluR3, cAMP, PKA and L-type calcium channel. Eur. J. Neuroscience 13:340-346, 2001.

Kozikowski, A. P., Nan, f., Conti, P., Zhang, J., Bzdega, T., Wroblewska, B., Neale, J. H., Pshenichkin, S., and J. T. Wroblewski. Design of remarkably simple, yet potent inhibitors of glutamate carboxypeptidase II (NAALADase). J. Medicinal Chemistry 44:298-301,2001.

Subramaniam, J. R., Corsi, L., Vicini, S., Whiting P. J. and J. H. Neale. Ribozyme-mediated reduction of the GABA(A) receptor alpha1 subunit. Mol. Brain Res., 92:149-156, 2001.

Rong, S-B., Zhang, J, Neale, J.H., Wroblewski, J. T., Wang, S. and A. P. Kozikowski. Molecular modeling of the interactions of glutamate carboxypeptidase II with its potent NAAG-based inhibitors. J. Medicinal Chemistry, 45:4140-52, 2002.

Bacich, D.J., Ramadan, E., O'Keefe, D.S., Bukhari, N., Wegorzewska, E., Ojeifo, O., Olszewski, R, Wrenn, C. C., Bzdega, T., Wroblewska, B., Heston, W. D. W., and J. H. Neale. Deletion of the glutamate carboxypeptidase II gene in mice reveals a second enzyme activity that hydrolyzes N-acetylaspartylglutamate. J. Neurochemistry. 83:20-29, 2002.

Ramadan,, E., Fu, Z., Losi, G., Homanics, G. E., Neale, J. H. and Vicini, S. GABA(A) receptor beta3 subunit deletion decreases alpha2/3 subunits and IPSC duration. J. Neurophysiol. 89:128-134, 2003.

Losi, G., Vicini, S. and Neale, J. NAAG fails to antagonize synaptic and extrasynaptic NMDA receptors in cerebellar granule neurons. Neuropharmacology, 46: 490-496, 2004.

Bzdega T., Crowe S.L., Ramadan E., Sciarretta K., Olszewski R.T., Ojeifo O., Rafalski V.A., Wroblewska B., Neale J.H. Cloning and characterization of a second enzyme with NAAG peptidase activity. J. Neurochemistry, 89:627-636, 2004.

Olszewski R., Bukhari R., Zhou J., Kozikowski A., Wroblewski J., Shamimi-Norri S., Wroblewska B., Bzdega T., Barton F., and Neale J. H. NAAG peptidase inhibition reduces locomotor activity and some stereotypes in the PCP model of schizophrenia via group II mGluR. J. Neurochemistry, 89:876-885, 2004.

Kozikowski, A. P., Zhang, J., Nan, F., Petukhov, P., Grajkowska, E., Wroblewski, J. T., Yamamoto, T., Bzdega, T., Wroblewska, B., and Neale, J. H. Synthesis of Urea-Based Inhibitors as Active Site Probes of Glutamate Carboxypeptidase II: Efficacy as Analgesic Agents. J. Medicinal Chemistry, 47:1729-1738, 2004.

Yamamoto,T., Hirasawa, s., Wroblewska, B., Zhou, J., Grajkowska, E., Kozikowski, A., Wroblewski, J., and Neale, J. H. Antinociceptive effects of N-acetylaspartylglutamate (NAAG) peptidase inhibitors ZJ-11, ZJ-17 and ZJ-43 in the rat formalin test and in the rat neuropathic pain model. Eur. J. Neuroscience, 20:483-494, 2004.

Gehl, L. M., Saab, O. H., Bzdega, T., Wroblewska, W. and J. H. Neale. Biosynthesis of NAAG by an enzyme-mediated process in rat spinal cord neurons and glia. J. Neurochemistry, 90:989-997, 2004.

Zhong C., Shao, X., Jayaprakash, S., Kozikowski, A., Neale, J. H., and Lyeth, B. G. NAAG peptidase reduces acute neuronal degeneration and astrocyte damage following lateral fluid percussion TBI in rats. Journal of Neurotrauma 22:266-276, 2005.

Neale J.H., Olszewski R., Gehl L. M. Wroblewska B. and Bzdega T. The neurotransmitter N-acetylaspartylglutamate in models of pain, ALS, diabetic neuropathy, CNS injury and schizophrenia. Trends in Pharmacological Sciences, 9:476-484, 2005.

Zhou J., Neale, J. H., Pomper, M. G., and Kozikowski A. P. NAAG peptidase Inhibitors and their potential for diagnosis and therapy. Nature Reviews Drug Discovery 4:1015-1026, 2005.

Wroblewska B., Wegorzewska I. N., Bzdega, T., Olszewski R. T. and Neale, J. H. Differential negative couplig of type 3 metabotrophic glutamate receptors to cGMP in neurons, astrocytes and mGluR3 transfected glioma cells. Journal of Neurochemistry, 96:1071-1077, 2006.
Zhong C. , Zhao X., Van K.C., Bzdega T., Smyth A., Zhou J., Kozikowski A., O’Connor W. T., Berman R.F., Neale J. H., and Lyeth B.G. NAAG Peptidase Inhibitor Increases Dialysate NAAG and Reduces Glutamate, Aspartate and GABA in the Dorsal Hippocampus after Fluid Percussion Brain Injury in the Rat. Journal of Neurochemistry. 97:115-125, 2006.

Saito O., Aoe T., Kozikowski A., Sarva J., Neale J. H., and Yamamoto T. Effect of systemic administration of morphine, alpha-2 agonist, NMDA antagonist and N-acetylaspartylglutamate (NAAG) peptidase inhibitor on bone cancer pain model in mice. Canadian Journal of Anesthesia. 53:891-898, 2006.

Yamamoto, T., Saito, O., Aoe, T., Bartolozzi, A., Sarva, J., Kozikowski, A., Wroblewska, B., Bzdega, T., and Neale, J. H. Local Administration of N-acetylaspartylglutamate (NAAG) peptidase inhibitors is analgesic in peripheral pain in rats. European Journal of Neuroscience, 25:147-158, 2007.

Olszewski, R.T., , Wegorzewska, M.M., Monteiro A. C, Krolikowski K, Zhou, J., Kozikowski, A.P., Long, K., Mastropaolo, J., Deutsch S. and Neale, J. H. PCP and MK-801 induced behaviors reduced by NAAG peptidase inhibition via metabotropic glutamate receptors. In press, Biological Psychiatry, 2007.

Yamamoto, T., Saito, O., Aoe, T., Zhou, J., Kozikowski, A. and Neale J. H. Intracerebraventricular administration of NAAG peptidase inhibitor is analgesic in inflammatory pain. Submitted to Pain, 2007.

Wroblewska, Bzdega, Olszewski and Neale, J. H. NAAG negatively modulates cGMP via mGluR3 but not mGluR2 receptors in transfected cells. In Preparation, 2007.

"Oldies but Goodies"

Neale, J. H. and I. Gray. Protein synthesis and retention of a conditioned response in rainbow trout as affected by temperature reduction. Brain Research 26:159-168, 1971.

Neale, J. H., E. A. Neale and B. W. Agranoff. Radioautography of the optic tectum of the goldfish after intraocular injection of 3H-proline. Science 176:407-410, 1972.

Neale, J. H., P. D. Klinger and B. W. Agranoff. Camptothecin blocks memory of conditioned avoidance in goldfish. Science 179:1243-1246, 1973.

Neale, J. H., P. D. Klinger and B. W. Agranoff. Temperature dependent consolidation of puromycin-susceptible memory in the goldfish. Behavioral Biology 9: 267-278, 1973.

Breakefield, X. O., E. A. Neale, J. H. Neale and D. M. Jacobowitz. Localization of catecholamine storage associated with granules in murine neuroblastoma cells. Brain Research 92:237-256, 1975.

Giller, E. L., J. H. Neale, P. N. Bullock, B. K. Schrier and P. G. Nelson. Choline acetyltransferase activity of spinal cord cell cultures increased by co-culture with muscle and by muscle conditioned medium. Journal of Cell Biology 74:16-29, 1977.

Barker, J. L., J. H. Neale, T. G. Smith, Jr. and R. L. Macdonald. Opiate peptide modulation of amino acid responses suggests novel form of neuronal communication. Science 199:1451-1453, 1978.

Neale, J. H., J. L. Barker, G. R. Uhl and S. H. Snyder. Enkephalin-containing neurons visualized in spinal cord cell culture, with cover photomicrograph. Science 201:467-469, 1978.

Sweetnam, P. M., J. H. Neale, J. L. Barker and A. Goldstein. Localization of immunoreactive dynorphin in neurons cultured from spinal cord and dorsal root ganglia. Proceedings of the National Academy of Sciences, USA 79:6742-6746, l982..

Westbrook, G. L., M. L. Mayer, M. A. A. Namboodiri and J. H. Neale. High concentrations of N-acetylaspartylglutamate (NAAG) selectively activate NMDA receptors on mouse spinal cord neurons in cell culture. Journal of Neuroscience 6:3385-3392, 1986.

Anderson, K. J., D. T. Monaghan, C. B. Cangro, M. A. A. Namboodiri, J. H. Neale, and C. W. Cotman. Localization of N-acetylaspartylglutamate-like immunoreactivity in selected areas of the rat brain. Neuroscience Letters 72:14-20, 1986.

Tieman, S. B., K. Butler and J. H. Neale. N-Acetylaspartyl-glutamate: A peptide in the human visual system. Journal of the American Medical Association, 259:2020, 1988.

Williamson, L. C. and J. H. Neale. The localization of N-acetylaspartylglutamate within synaptic vesicles of retinal neurons. Brain Research, 456:375-381, 1988.

Sato, T. N. and J. H. Neale. Immunological identification of multiple alpha-like subunits of the GABAA receptor complex purified from neonatal rat cortex. J. Neurochem. 53:1089-1095, 1989.

Moffett, J. R., L. C. Williamson, J. H. Neale, M. Palkovits and M. A. A. Namboodiri. Effect of optic nerve transection on N-acetylaspartylglutamate immunoreactivity in the primary and accessory projection systems in the rat. Brain Research, 538:86-94, 1991.

Williamson, L. C., D. A. Eagles, J. R. Moffett, M. J. Brady, M. A. A. Namboodiri and J. H. Neale. Localization and synaptic release of N-acetylaspartylglutamate the chick retina and optic tract. European Journal of Neuroscience, 3:441-451, 1991.

Wroblewska, B., J. Wroblewski, S. Pshenickin, A. Surin, S. Sullivan and J. H. Neale. NAAG selectively activates mGluR3 receptors in transfected cells. J. Neurochem. 69: 174-181, 1997.

Ghose, S., B. Wroblewska, L. Corsi, D. R. Grayson, A. L. DeBlas, S. Vicini and J. H. Neale. NAAG stimulates mGluR3 to regulate expression of the GABA-A alpha 6 subunit in cerebellar granule cells. J. Neurochem. 69: 2326-2335, 1997.

Bzdega, T., T. Turi, B. Wroblewska, D. She and J. H. Neale. Molecular cloning of a peptidase against N-acetylaspartylglutamate from a rat hippocampal cDNA library. J. Neurochem. 69:2270-2277, 1997.

Wroblewska, B., M. R. Santi and J. H. Neale. N-Acetylaspartylglutamate activates cyclic AMP-coupled metabotropic glutamate receptors in cerebellar astrocytes. Glia 24: 172-179, 1998.